Author Topic: Substitute for NaI in TMSCl Reductions?
ReFlux
Member posted 09-01-98 02:17 PM
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Referring to the topic of hypothetically reducing ephedrine to meth. using chlorotrimethylsilane + NaI + Acetonitrile (see Tett. Lett. Vol. 28, 33 Pg3817-3818 (1987) also see various topics regarding this reaction in this forum), Is it possible to substitute the Sodium Iodide (NaI) with potassium Iodide (KI)?
The reasons are obvious, in that KI is used in table salt and is easier to obtain.
What are your thought?
-ReFlux
Rhodium
Administrator posted 09-02-98 05:54 PM
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The KI in table salt is present in amounts less than 0.01% - not extractable.
ReFlux
Member posted 09-02-98 06:32 PM
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I understand that, but since it is used in the table salt industry, it can be purchased more readily and is also much cheaper.
-ReFlux
