The Hive > Tryptamine Chemistry

Indole Grignards

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Tsathoggua:
If the corresponding n,n-dimethyltryptamine were the intended target, it could serve as a precursor for psilocin, methinks, via catalytic removal of the benzyl group to give psilocin, and subsequent esterification would be a good idea, due to the instability of 4-OH tryptamines.

Beard:

--- Quote from: Tsathoggua on February 05, 2017, 04:46:59 AM ---If the corresponding n,n-dimethyltryptamine were the intended target, it could serve as a precursor for psilocin, methinks, via catalytic removal of the benzyl group to give psilocin, and subsequent esterification would be a good idea, due to the instability of 4-OH tryptamines.

--- End quote ---


David E. Nichols does exactly ALL of that starting with 4-benzoyloxy-indole (and goes directly from 4-benzoyloxy-DMT -> 4-Acetoxy-DMT) here: https://www.erowid.org/archive/rhodium/pdf/nichols/nichols-psilocin.pdf

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