Goal: Convert 1000 tablets of MSIR (Morphine Sulfate Instance Release) to Morphine base, or HCL.
For further conversion to diacetylmorphine (heroin). (Note Tried acetylation with MS mother liquid and acetic anhydride, yield dark brown liquid cleaned it up with chloroform, etc…. But everything I’ve read say you must start with Morphine base
Or HCL. So one step at a time, trying to convert the MS to morphine base or HCL.
But just in case:
Question: Does one really have to start with Morphine base or HCL to make
diacetylmorphine?After researching the-hive followed two threads that seemed to provide the info I was looking for.
I've attached them to this post.
To convert Morphine Sulfate "MS" to its base (Morphine) I tried to do the following:
I added ammonium hydroxide (dilute soln.) in excess to the mother liquid. (Mother liquid was completely saturated MS) 1st problem was what is the actual concentration of ammonium hydroxide (dilute soln.) suppose to be??? The best I could go by was the definition for dilute soln for ammonia which is suppose to be (Molarity 6/L or 102g/L) The ammonium hydroxide I used was listed as 57%, so from there I attempted to dilute it accordingly, basically added H2O @ a 3:1 ratio.
The problem is the morphine did not precipitate well and what did/does re dissolved, however, my problem may have been that I failed to monitor the PH.
So after further reading I think one needs to add NH4OH to the mother liquid until a PH of
9.1 is achieved? Then the mixture is vigorously shaken and placed in a refrigerate over night.
(According to poppystraw)
Question: As the Morphine crystals precipitate will the PH of the mixture change by any significant amount, and if so does one need to continue to adjust it?Note MSIR is Morphine + H2SO4 + 5H2O a 30mg pill weights 44mg, (remember their hypodermic tablets) in addition they may contain either lactose or sucrose or both.
Best thread on this subject I found so far was:
Post 48274 (missing)
(poppystraw: "Re: morphine sulfate to heroin hcl", General Discourse)A post from poppystraw on this thread read:
A)
Morphine sulfate to heroin hcl Bookmark
The following steps should be observed
1) to convert the morphine sulfate to morphine base use minimum amount H2O...filter undissolved pill matter with buchner funnel...then add ammonium hydroxide which will precipitate out the free base morphine
2) next extract morphine base from aqueous environment with toluene/butanol mixture.....if the morphine base is contaminated with other materials....ususally one checks the melting point to determine purity...if M.Pt is low use the toluene/butanol mixture 1:1 ratio...if the melting point is sharp skip the purification step
3) precipitate as tartaric acid (important purification step)
4) finally convert tartrate to free base then use acetic anhydride to convert the morphine free base to heroin,then convert the heroin base to the HCl or sulfate salt
B) he splells it out better but steps 2, 3, and 4 are vauge.
(also he implies I should get 100% purity (no loss, he states "100 pills of MS @10mg/pill yields
1000mg of morphine base) any thought
)
Re: morphine sulfate to heroin hcl Bookmark
Morphine 90cc
If you wish to convert the morphine sulfate to heroin you must convert the acid salt (morphine sulfate) to its free base.....this is accomplished by first disolving the morphine fron the pills in distilled water, minimum amount....filter using buchner funnel...next very carefully add ammonium hydroxide(dilute soln.) in excess to the mother liquoid...vigorously shaking....a white precipitate is formed....cool the soln in the refrigerator over night to allow maximum crystal growth...filter using buchner.....sometimes reducing the amount of mother liquid is helpful to obtain more crystals of morphine..cool and filter again....the resulting white powder is morphine free base...the above procedure works for the acetate, hydrochloride, and sulfate salts of morphine.....this freebasing procedure is a good source for morphine base however it takes about 100 pills @ 10mg morphine to produce 1000mg of morphine base...one gram...
The tartaric acid purification procedure is used whenever very pure morphine base is required...generally this methid is used when recovering morphine base from poppy straw extract which contains a variety of plant alkaloids...and separation of simular compounds is difficult.....
Now to convert the morphine base to diacetylmorphine, you will need acetic anhydride or acetyl chloride....this is a very common procedure and can be found this web-site under opioids......however, you might view this forum under opium poppy garden....another posting is morphine base to heroin
_________________________________________________________________________
2nd best post/thread I found was:
2. Rhodium wrote in thread :
Post 209556 (missing)
(taig: "morphine sulfat -> morphine hcl", Newbee Forum)morphine sulfat -> morphine hcl Bookmark
From Us Pat 6,054,584 (
https://www.thevespiary.org/rhodium/Rhodium/chemistry/morphextr.html
)
"Finally, the morphine free base is precipitated out of the resulting aqueous solution by adjusting the pH of the aqueous filtrate to pH 8.5 to 9.5. Preferably, the pH to precipitate the morphine ranges from about 9 to 9.3, and most preferably is about 9.1"
End of 2nd thread
As my hive name implies I'm serious and will report all findings back the the-hive!!! Please direct me via this post or PM to any additional info or site, etc...
Thank you
Really Serious