OK,
So if theoretically one wanted to do a thermal rearrangement but didn't have th correct high boiling point solvent, and decided to uses an alternative (ultrasene). What temperature should one use to acheive maximum yeild?
I know in the patent (see below) that they use Decalin and it's bp is 195.8'C (cis) or 187.3 (trans) and heat it to 180'C. So what should I do if the bp of my ultrasene is much higher (around 175-325????). I have done the heating till around 180'C but am not sure if I should continue to much higher because techniquily that is not a reflux.. right?
the patenet is:
Patent PAtentUS3254124 (http://l2.espacenet.com/dips/viewer?PN=PAtentUS3254124&CY=gb&LG=en&DB=EPD)
Wellyour right.. I know that refluxing is.. but the thing is that the ultrasene is only the solvent.. the actual material that I am rearranging is a ketamine precusor... and that has a bp.. of... I dunno.. like... under 180 sicne it did that in the patent.. I jsut am wondering to increase the yeilds.. should the solvenet also be near refluxing?
since bp is whatever I menitioned before... anywyas..thanks.. I dunno... what else to say...
but the bp are correct check this link...
https://www.thevespiary.org/rhodium/Rhodium/pdf/chemical-data/solvents.pdf (https://www.thevespiary.org/rhodium/Rhodium/pdf/chemical-data/solvents.pdf)
anways maybe my patent location is wrong 1 sec...
Patent US3254124 (http://l2.espacenet.com/dips/viewer?PN=US3254124&CY=gb&LG=en&DB=EPD)
now patent works...