Post 509654 (missing)
(dennis_pro: "Èëëþñòðèðîâàííîå äåêàðáîêñèëèðîâàíèå", Russian HyperLab).Post 512109 (https://www.thevespiary.org/talk/index.php?topic=13038.msg51210900#msg51210900)
(jemma_jamerson: "purifying tryptamine and co2", Tryptamine Chemistry):
Patent US2943093 (http://l2.espacenet.com/dips/viewer?PN=US2943093&CY=gb&LG=en&DB=EPD)
gives a method for purifying tryptamine compounds by treatment with CO2 in a solvent to form the carbonate which precipitates from the solution. CO2 is in the air. I wonder if this could cause problems when handling tryptamines. Tryptamine carbonates tend to be insoluble in solvents like alcohol and methylene dichloride. Heating the tryptamine carbonate decomposes it into the tryptamine and CO2.
Maybe you should try this out on the product you've obtained..
Post 509654 (missing)
(dennis_pro: "Èëëþñòðèðîâàííîå äåêàðáîêñèëèðîâàíèå", Russian HyperLab)Post 476610 (missing)
(Erny: "Äåêàðáîêñèëèðîâàíèå òðèïòîôàíà a la Student", Russian HyperLab)https://www.thevespiary.org/rhodium/Rhodium/hyperlab/syntheses/tryptophane_.decarbox.htm (https://www.thevespiary.org/rhodium/Rhodium/hyperlab/syntheses/tryptophane_.decarbox.htm)
did not bring a desired result when performed under our conditions.http://www.millenniumchem.com/NR/rdonlyres/6C43C1E8-EFAD-42E4-8357-4A519E99B743/0/PEPPERMINTOIL540.pdf (http://www.millenniumchem.com/NR/rdonlyres/6C43C1E8-EFAD-42E4-8357-4A519E99B743/0/PEPPERMINTOIL540.pdf)
Post 509761 (missing)
(Nicodem: "Mechanism of decarboxylation literature", Tryptamine Chemistry)Post 509782 (missing)
(Rhodium: "Catalytic transamination/decarboxylation cycle", Tryptamine Chemistry)Your reaction mixture seems to be reddish right from the start. What's the trick to get it working?
The reaction brings some reddish color immidiately after heating to 150 C. Some tryptophan dissolves, evolution of CO2 starts and mix brings some reddish. No special tricks.
Lilienthal:
How have you tested if it is indeed tryptamine and not a cyclization product?
I haven't measure the melting point of the product (i haven't a thermometer :(), but all phys-chem properties shows that it is tryptamine. Moreover, it was alkylated with EtBr and the products was show the activity. I planned some experiments in future, where all will be measured right.
Vitus_Verdegast:
Nice translation, thanks.
don't see one on the pictures
Yes, the stirring was completed by hands when the foam rised up to condenser.
That last part of the sentence, is that correctly translated?
Yes, this is correct.
The general output not of schitan, since with the experiments separation of candy (tryptamine) from govna resin) product threw out itself on nemnogu into the toilet.
Politicaly correct translation is: "The total yield was not calculated, since during of the reaction workup (purifying the tryptamine from the resin byproducts), much of the reaction mixture was discarded"
The use of the organic (?) solvents
Correct.
You didn't tell us what your final yield was
The total yield i obtained was 2g (from 20g tryptophan). But much, very much of the reaction mixture was discarded when i was tried to remove resins by recrystallization, A/B reextraction, trying various solvents, etc. You can obtain good results with using of inert gas and provided instructions. (My workup was completed during 2 days, without protection reaction mixture from air: slightly reddish reaction mixture makes intensively red after these days. Oxidation?)
Future questions are welcome. Thanks again.
P.S. Sorry for my terrible english.
Post 478376 (missing)
(Erny: "Äåêàðáîêñèëèðîâàíèå òðèïòîôàíà - áåòà âåðñèÿ", Russian HyperLab) (1)