The Hive > Novel Discourse

Methylone synthesis

(1/4) > >>

Chicken:
Do any bees know where a synthesis might be found for methylone, 2-methylamino-1-(3,4-methylenedioxyphenyl)propan-1-one.  There are some journal entries regarding it's effects which are, in thses articles it states that the methylone was synthed, but does not indicate what the synthesis proceedure is.  There alslo are several reports for usage on erowid at 

Inhibition of Plasma Membrane Monoamine Transporters by b-Ketoamphetamines,
Cozzi NV, Sievert MK, Shulgin AT, Jacob Peyton III, Ruoho AE
Eur. J. Pharmacol, 1999; 381:63-69 Post 493183 (missing) (Rhodium: "Methcathinone & Methylone Pharmacology", General Discourse)
 
Methcathinone and 2-methylamino-1-(3,4-methylenedioxyphenyl)propan-1-one (methylone) selectively inhibit plasma membrane catecholaminereuptake transporters,
Cozzi NV, Sievert MK, Shulgin AT, Jacob Peyton III, Ruoho AE
Soc. Neurosci. Abs, 1998; 24: 381.8

Methcathinone (MCAT) and 2-methylamino-1-(3,4-methylenedioxyphenyl)propan-1-one (MDMCAT) inhibit [3H]serotonin uptake into human platelets,
Cozzi NV, Shulgin AT, Ruoho AE
Amer. Chem. Soc. Div. Med. Chem. Abs., 1998; 215: 152

Rhodium:
3,4-Methylenedioxybenzene + Propionic acid + Polyphosphoric acid -> 3,4-Methylenedioxypropiophenone

3,4-Methylenedioxypropiophenone + N-Bromo-succinimide -> alpha-bromo-3,4-Methylenedioxypropiophenone

alpha-bromo-3,4-Methylenedioxypropiophenone + Methylamine -> Methylone

PrimoPyro:
Please tell me you can do the same reaction with formic acid, making piperonal.
Will perform sexual favors for females in exchange for 1,2-dimethylaziridine. PM for details.

Rhodium:
Here is a reference for the reaction: https://www.thevespiary.org/rhodium/Rhodium/chemistry/acetophenones.html

I have never heard of the reaction (which essentially is a FC acylation with PPA as the lewis acid) being used with formic acid. There is nothing that would stop any formed piperonal from acylating unreacted benzodioxole, so I guess your suggestion would be a dead end...

The following is a rather old Methylone patent: Patent US3523954

Osmium:
Formic + strong drying agent -----> CO + CO2
I'm not fat just horizontally disproportionate.

Navigation

[0] Message Index

[#] Next page