LSD via the following method.
Dissolve 0.536g (I) in 10 ml freshly distilled POCL3; stir and add 416mg powdered, freshly sublimed PCl5. Hold two minutes at room temperature, two minutes at 90°C, and evaporate in vacuum. Extract the residue with hexane to give the lysergic acid chlo ride-HCl (can also extract the reaction mixture with hexane instead of evaporating in vacuum). Alternatively use 6ml POCl3 and 240 mg SOCl2 and heat three minutes at 90°C to get the acid chloride. To 5g of the acid chloride add 1.4ml DEA in 50ml methane chloride and cool to 0°C. Stir and add 27.5 ml pyridine and stir 1/2 hour at 0° . Warm to room temperature and stir 11/2 hours. Evaporate in vacuum to get LSD.
I don't know about the validity of that synthesis, but either way, that synthesis uses lysergic acid as the precursor, not lysergic acid amide.
There are no reasons. Who needs reasons when you've got heroin?
