provided one has a rotovap and inert gas setup
Inert gas setup: argon/nitrogen tank, im sure these can be got from welding, regulators, just make friends with a welder and all your problems are solved. Into a 2-holed stopper in a flask place some glass tubing extending down to the bottom of the flask, and in the other hole, a bit of tube and connect it to a very VERY weak valve so you dont overpressurise enough to blow the vessel. Im talking like, even a water airlock would be sufficient. Charge the vessel with your solvents and chemicals, and very slowly regulate some inert gas through the solvent/chemical solution and up into the flask. This will create positive pressure blowing the air out of the flask, and also by bubbling it through the solution (argon/nitrogen won't react easily at all) you will remove any dissolved oxygen/Co2. After you've flushed the flask (do an oxygen/co2 test at the end of the water-airlock) turn off the gas and leave it connected. Voila, one reaction vessle with no air in it.
A rotovap would be handy, but shouldnt really be necessary, if one chooses the right solvents simply evaporating under vaccum should be fine. But if one insists, there is a ghetto-prep for a rotovap on Rhodium's site.
But a problem which arises no matter if CDI, BOP, pyBOP or others are used: how much woodrose seeds would one bee have to extract to get sufficient (lets say 1g) precursor after thorough purification?
Again on Rhodiums page, 200grams of woodrose seeds would provide roughly 1 gram of LSA which upon hydrolysis using NaOH or KOH 0.5gm of usable lysergic acid. But, SWIM just read about using tetrabutylammonium hydroxide at 30C for 20 hrs to yeild 80% with less than 3% of iso. Figuratively speaking, at less than 3% iso, a person may not even choose to seperate that isomer as it won't do anything anyways, and it's in such small quantity (keep in mind, purity is your god).
200gm of seeds is easy to come by. Even taking say 20 seeds and planting them out, in 2 years you'd have a sustainable source of woodrose seeds. SWIM's friend's 2 year old plant covers a whole side of his house, and regular pods have 4 seeds in them. Plus, they seed twice a year, so one could take multiple harvests and place the seeds into a vaccum bag and suck all the air out, keeping it in a dry dark place should preserve them from degredation until enough seeds can be aquired.
[/blue]And 50 gallons of solvent?
For 200gm seeds, 1liter of nonpolar and 1liter of slightlypolar solvent were used. I think 2L of solvent is jusitified for a person's private lifetime amount of 'cid.
but I agree with you: the product justifies every work and hassle, as long as you don't deal with a serious health hazard
woodrose seeds --> toluene defat --> A/B extract to Lysergic Acid tartarate --> dump in some tetrabutylammonium hydroxide (exotic yes, but worth it, shouldn't be watched) to get 80% usable lysergic acid with a trace of iso-lsd, removed by changing PH and filtering, then reverting to original PH. DEET bug repellent can be bought anywhere, dump that into 10% NaOH re:rhodium's post and distill into hcl, boill off the water to get diethylamine. Dump 1eqmol lysergic acid into 1.05 eqmol PyBOP reagent and 2 eqmol diethylamine, keep it stirring for 3 hours, remove the lsd with a solvent, and chromatograph as freebase or tartarate salt.
Nothing here is really toxic or that dangerous, and because you only really need one chromatograph at the end (presuming you defatted the seeds like a mofo and you acid/base extracted correctly), so almost all of this can be done in the dark or with minimal light and therefore could be done in a day easily. Prepare everything beforehand, and even if you have to bring it into the light for 10 seconds to see what you're doing, big deal, no massive degredation.