Title: That is Crazy
Post by: PrimoPyro on October 08, 2002, 12:12:00 PM
If one wants to use a Grignard reaction to prepare an aldehyde, just use DMF, it would be much simpler, wouldn't it?
When I saw this, I was more interested in possible ways to prepare psychoactive oxazolines with this method, rather than benzaldehydes. Food for thought. Thanks. :)
PrimoPyro Firm supporter of the "Purge The Couch!" movement. Vote for the purge today.
Title: I often wonder if these chemists do not care at ...
Post by: Osmium on October 08, 2002, 03:39:00 PM
I often wonder if these chemists do not care at all what their syntheses cost, all that matters is yet another publication in yet another journal. Why does that shit have to get more complicated and involved all the time? Yeah I know, publish or perish. But still. Pisses me off. I'm not fat just horizontally disproportionate.
Title: Optimization is just SO last century...
Post by: Rhodium on October 08, 2002, 05:36:00 PM
They don't care what their syntheses cost per mole of product, as they are never performing any of the syntheses on a scale larger than 1 mmol anyway (in 50ml of degassed anhydrous THF distilled from LAH and covered with a blanket of argon, and the 0.93 mmol of product detected by GC before or after eluting it through 50g of silica gel using 500ml of some exotic solvent mixture)...
Title: another publication
Post by: Bwiti on October 09, 2002, 01:07:00 PM
"all that matters is yet another publication in yet another journal."
It's people like them that give people like us more options. :)