Studies on Several 7-Substituted N,N-Dimethyltryptamines
Glennon, R. A.; Schubert, E.; Jacyno, J. M.; Rosecrans, J. A.
J. Med. Chem. 23(11), 1222-1226 (1980) (https://www.thevespiary.org/rhodium/Rhodium/pdf/7-substituted.dmt.pdf)
(https://www.thevespiary.org/rhodium/Rhodium/pdf/7-substituted.dmt.pdf)
Medline (PMID=6779006) (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6779006&dopt=Abstract)
Abstract
Several 7-substituted derivatives of N,N-dimethyltryptamine (DMT) were prepared and evaluated in the rat fundus serotonin receptor assay and in a behavioral (discriminative stimulus) assay in rats. Both 7-Me- and 5-MeO-7-Me-DMT possess a higher pA2, and 5,7-(MeO)2-DMT a lower pA2, than that of DMT itself. Like DMT, all three of these compounds produce behavioral effects in rats which are similar to those of the hallucinogen 5-MeO-DMT. Although 7-Et- and 7-Br-DMT possess a higher serotonin receptor affinity than DMT, neither produce behavioral effects which parallel those of 5-MeO-DMT. In contrast, 6-MeO-DMT and its 5-MeO derivative do not interact with the serotonin receptors in a competitive manner and are inactive in the discriminative stimulus assay.