Post 357689 (https://www.thevespiary.org/talk/index.php?topic=7216.msg35768900#msg35768900)
(Osmium: "Solubility of compounds", Chemistry Discourse)http://bcis.pacificu.edu/~polverone/alkaloids.html (http://bcis.pacificu.edu/~polverone/alkaloids.html)
):ALKALOIDS OF STRYCHNOS SPECIES
Strychnine and brucine occur most abundantly in nux-vomica seeds (Strychnos Nux-vomica, L.) and Ignatius beans (S. Ignatii, Berg.). Both drugs contain from 2 to 3 per cent, of alkaloids, of which about one-half is strychnine in the former and two-thirds in the latter, the rest being mainly brucine.
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For the extraction of strychnine and brucine on a laboratory scale the finely ground Strychnos seeds may be mixed with slaked lime and made into a stiff paste with water. This is dried at 100°, powdered, and exhausted with boiling chloroform. From this the alkaloids are removed by agitation with dilute sulphuric acid, which is then filtered, excess of ammonia added, and the precipitate extracted with 25 per cent, alcohol, which dissolves the brucine and leaves most of the strychnine undissolved. The latter is purified by recrystallisation from alcohol, in which brucine is more soluble.
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The base is slightly soluble in water (1 in 6,400 at 25°, 1 in 3,000 at 80°) or ether (1 in 5,500 at 25°), more so in 90 per cent, alcohol (1 in 110 at 25° or 1 in 28 at 60°), or benzene (1 in 150 at 25°), readily so in chloroform (1 in 6 at 25°).
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Strychnine nitrate, B.HNO3, occurs in colourless shining needles, soluble in water (1 in 42 at 25°), alcohol (1 in 120 at 25°), or chloroform (1 in 156 at 25°); laevorotatory. The sulphate, B2.H2SO4.5H2O, forms colourless prismatic crystals, m.p. 200° (dry), and is soluble in water (1 in 31 at 25°), or alcohol (1 in 65 at 25°), less so in chloroform (1 in 325 at 25°). The hydrochloride, B.HC1.2H2O, forms colourless, efflorescent, trimetric prisms, soluble in cold water (1 in 35) or alcohol (1 in 80).
If these figures are reliable, strychnine and its salts are both more soluble than you had been lead to believe. Are you going to try to remove the brucine? Can you at least get alcohol? Are you positive that you can't get any other solvent and/or acid? Sometimes you just have to know where to look.