dual and combined NP solvent washes?

[halfkast]

What would you rate combining 2-4 non-polar solvents on an advisability scale?

Mainly for yield concerns and broader problem solving when dealing with unknowns.

Any guidence?

[rudebwoy]

Post 343523 (missing)

(Rhodium: "Solvent Miscibility Chart", Newbee Forum)
Check on the list.
If the nps don't separate great.

[Rhodium]

Combined non-polar solvents are almoist always bads, unless you know exactly why you are combining which solvents.

A good idea is to first extract with a "weak" np, like petroleum ether or hexane/pentane (or maybe naphta), as this might be strong enough to extract what you want, but not the things you don't want.
 
Then you move on to more polar ones, the second group being diethyl ether or toluene (maybe carbon tetrachloride) (this will dissolve most common substances we want to extract, but usually not the stickiest of tars, polymers etc).

Finally, you can use ethyl acetate or dichloromethane (maybe chloroform) if you really want to extract EVERYTHING organic from an aqueous phase, this includes sticky tars, polymers and a lot of similar gunk (as well as almost anything we usually want as products.

[halfkast]

rudebwoy, rhodium uplifting to hear from you.

Sorry for not returning sooner, your advice was beeing appreciated days ago but I didn't have time to reply nicely. I did this offline, I hope it's easy for you to understand.

OK, Ill remember this. You mention aqueous phases a lot in this process...so forgetting “dry matrix” and pseudoephedrine thoughts... Its nice to operate on an aqueous phase starting point with NP's and immiscible solvents?

Do you know of any tricks to exploit when everything is dissolved in either a single of solvent?

How would the dissolved group of substances tend to settle when evaporated: (a) Much the same as they were, (b) rough layers of molecular weights, (c) or usually a highly unpredictable and an insignificant matter, (d) something else?

If there was much more comprehensive temperature-solvent-substance solubility data around things would be a lot more straight forward and fun.. =)
I'm interested to know, whats the most comprehensive database, is the Merck Index the limit for solubility data?

What about solubility prediction, is this a meaningless area of chemistry?

[rudebwoy]

I thought we were talking about washing, not extracting. 

How would the dissolved group of substances tend to settle when evaporated: (a) Much the same as they were, (b) rough layers of molecular weights, (c) or usually a highly unpredictable and an insignificant matter, (d) something else?


a)  why do u want mixtures of substances in one pot.  to cut the shiznat? 
b)  molecular weight is how many moles per liter so technically yes?  but something you shouldn't really care about cuz it's ittybitty very tiny weight?
I dunno
c) highly unpredictable?
i still think yer trying to cut yer shit and crash out the crystals out of the solution and make it so u're not just coating yer crap to people.  u actually integrate it in to the crystals. 

unpredictable
i think there's too many variables for my poorn uneducated brain to decide. 
for hell we know, the moon's gravity could be affecting it.  it sure affects the tide of the ocean.
get the drift?

[halfkast]

rudebwoy, you have a different drift I feel.

Here's where I think the confusion is: Your thinking "pot", I'm thinking beaker; your thinking "shiznat" and I'm thinking partially mysterious powders and other interesting plant material and substances in the future maybee.

I don't really differentiate much between extracting and washing. I don't have in mind crystalisation as the following step to the extraction talked about here, so just extracting as in a general process of separation.

Excuse me? I'm not trying to cut anything for anybody, I have never attempted an illegal reaction and I wouldn't know how/where to go about/to selling drugs and the people I know aren't that way inclined...

I was following on from the last step in rhodiums procedure! Read it just ^^^there!


>>b)  molecular weight is how many moles per liter so technically yes?  but something you shouldn't really care about cuz it's ittybitty very tiny weight?

Hah yeah that isn't right! Thats molarity lol

[rudebwoy]

Washing and extracting is doing 2 diff things.
if you can't differentiate the two then . . .

umm.. what else. 
Why don't you explain what dream you had in mind and which step then perhapse we can help you better instead of stabbing at the moon.

[halfkast]

HAha man you've got this bee cracking up so bad, sorry.

Honestly, I don't have a reaction in mind. Is it so hard to believe that I'm enjoying learning about chemistry relevant to drug chemistry of course so that I can bee free to dream freely in relative privacy while gaining the knowledge to answer increasingly difficult questions others have?

Think about it, if you learn about reductive aminations, distillation, aromatic rings and functional groups, oils, isomerisation and misc. things here in-depth aswell as basic chem then at some point I figure that it will lead me to the know-how to bee able to dream a lot of the things in Pihkal or Tihkal. Where beautifully written synthesis and bioassays are to bee read and The Hive is where the shiznat is old hat I see.  
Find "Amp potent LSD", read it, I haven't got the foggiest idea what is going on but it sure is inspiring. On that note, don't you want to be able to dream LSD before you die, as your magnum opus perhaps? I do!  

I don't want a career in making methamphetamine or MDMA or other. If I take that path I will fry my brain and not bee able to learn( ), or Ill get so badly side-tracked itll bee out of control.

So yeah in short I'm not gonna fucken tellya I am dreaming about cleaning pseudafed mike because I would have asked that in the stimulants forum, and plus have a look at what rhodi wrote, hes describing general good procedure I think.

[rudebwoy]

*shrugs*

extraction and washing are two different techniques.  You ought to know between the two before learning anything else.

[edit] lsd?  Why don't you first learn what washing and extracting is before you read more up on your lsd fantasy.
[/edit]

[halfkast]