I know that this is a well covered subject on The Hive, but for those who want to read and a nice patent, I have made a nice link:
http://l2.espacenet.com/espacenet/bnsviewer?CY=gb&LG=en&DB=EPD&PN=GB836083&ID=GB++++836083A++I+ (http://l2.espacenet.com/espacenet/bnsviewer?CY=gb&LG=en&DB=EPD&PN=GB836083&ID=GB++++836083A++I+)
It seems that one can scale up the Bruylants reaction to a considerable extent (cfr. example 1)