The Vespiary

The Hive => Chemistry Discourse => Topic started by: cookin_4_1 on December 03, 2002, 09:20:00 PM

Title: 4 fluoroamphetamine
Post by: cookin_4_1 on December 03, 2002, 09:20:00 PM

Is 4-fluoroamphetamine smoke-able???

Title: why not?
Post by: yellium on December 03, 2002, 09:35:00 PM

why not?

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Hardcore libertarians consider the idea of a Libertarian Party dangerously socialist.

Title: Some info on this compound...
Post by: MK_801 on December 10, 2002, 09:21:00 AM

4-fluoroamphetamine should NOT have any MDMA like effects(as some report), but should strongly resemble amphetamine.

I just looked over a study (Marona-Lewicka D, Rhee GS, Sprague JE, Nichols DE. Psychostimulant-like effects of p-fluoroamphetamine in the rat. Eur J Pharmacol. 1995 Dec 12;287(2):105-13.) -- Sprague and Nichols do the COOLEST research, and it seems that 4-FA is most similar to straight up amphetamine, and does not share many similarities (at least in rats) with MDMA and other drugs (MMAI, etc) that act on serotonin. Other research I looked at confirmed this idea -- 4-FA appears to have virtually no effects on serotonin (less even than amphetamine).

4-FA had more more potent but less selective dopaminergic effects than d-amphetamine.

Fluorination of amphetamine also causes the drug to be eliminated from the brain more quickly. So, the effects won't last as long as amphetamine's (this could be a good thing).

Title: Other halo analogues
Post by: odin on December 19, 2002, 10:00:00 PM

What about p-(chloro, bromo, iodo)amphetamine. Is there anything in literature about these compounds (I havent found anything about pharmacology) . Can they be toxic ?

...hmmmmm too many questions

Title: They are very toxic serotonergic neurotoxins, ...
Post by: Rhodium on December 19, 2002, 10:43:00 PM

They are very toxic serotonergic neurotoxins, utfse.