Building an MD Bridge

[Vibrating_Lights]

Would it be at all possible to build an MD Bridge onto a Racemic Methamphetamine Freebase.

[Chromic]

Not at all practical, UTSE for explanations (how are you going to attach atoms, selectively, at the 3 and 4 positions?). You'll see that it's much more practical to use something that is 3,4-dihydroxy substituted to build the bridge.

[Vibrating_Lights]

would 3,4-dimethoxphenalacetone be a suitable canadite for Bridge construction prior to amination to produce MDP2P.

[boppesz]

I think you better make the amine first, than demethylate the methoxys and form a methylenedioxy with DCM and a PTC.

[sunlight]

Casually I have a refence for methylenation of methyl 3 methoxy 4,5 hydroxy benzoate, it's the previous text in CA to the isosafrol epoxide.
I don't know if it can be interesting, but may be:
CA 107:39789s
Methyl 3 methoxy 3,4 hydroxy benzoate (I) was cyclocondensed with CH2Cl2 in the presence of alakli metals halides, e.g. KI, NaI , to give the methylene dioxy benzaote derivate . This procedure shortened the reaction time from 40 to 2.5 h. and increased the yield of methyl 3 methoxy 3,4 methylenedioxy beonzoate from 68 to 79 %. A mixt. of K2CO3, CH2Cl2 and NaI in DMF was refluxed for ~ 0.5 hours; I in DMF was added over 15-30 min. , more CH2Cl2 was added , and the resulting mixt. refluxed for 1-2 hours to give II 79 %.