Author Topic: Methoxamine  (Read 1688 times)

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Vibrating_Lights

  • Guest
Methoxamine
« on: June 03, 2002, 07:12:00 AM »
Looking at the chemical structure of Methoxamine is it concieveable then that the 2-amino-1-(2,5dimethoxyphenyl)-1-propanol could be reduced via HI to the amphetamine. or any of the various ephedrine pathways.
VL_

PrimoPyro

  • Guest
I believe this has been brought up before, and it ...
« Reply #1 on: June 03, 2002, 07:16:00 AM »
I believe this has been brought up before, and it was concluded that, at least with the HI reduction, the methoxy groups would be torn to pieces.

PolytheneSam

  • Guest
How about this? Post 178931 us 2243295
« Reply #2 on: June 03, 2002, 07:29:00 AM »
How about this? 

Post 178931 (missing)

(PolytheneSam: "PPA --> meth this easy?", Chemistry Discourse)

Patent US2243295



http://www.geocities.com/dritte123/PSPF.html
The hardest thing to explain is the obvious

obia

  • Guest
things from methoxamine
« Reply #3 on: June 05, 2002, 01:11:00 AM »
should reduce with cat h2 and a small amount of phosphoric acid to 2,5 dma. the phosphoric acid shouldn't cleave the meos.
it could be brominated then oxidised to dob (cath)inone. there might be a problem with the hydroxy group being chewed up. I would guess that dob-inone would be have a few unwanted cardiovascular effects though

or it could be turned into an aminorex derivative, possibly with a halo 4 substituent added in prior to ring closure.

I guess though that economics dictate it isn't going to be a good starting material.