There are a variety of reasons to not want to try certain things and I can think up a few reasons:
- 1) Addiction Potential
- 2) OD Liability -- Small margin between ED50 and LD50
- 3) Toxicity -- (Acute/Chronic/Cumulative)
- 4) Psychological Drawbacks -- Psychosis, Mania, Compulsion, Extreme Depression, etc.
- 5) Environmental -- Will synthesis byproducts and waste or metabolic products be damaging to the environment in either an immediate or cumulative fashion?
I want to crowd source a list of things for which any reasonable clandestine chemist would advise extreme caution against the creation or use of. I'll go first:
Addiction: Fentanyl or its other piperidine or open-chain cousins. I know that I'd be dead in a week (most likely during work-up).
OD Liability: Another hat off to the ultra-powerful opioids. However, there are tropane analogues and a piperazine called 3C-PEP that looks like it would eviscerate anyone unfortunate enough to try it.
Toxicity: a-PVT, the thiophene analogue of a-PVP, is absolutely something to never ingest by any ROA. As far as I can tell, I am the only person who has intentionally ingested this compound and I must say it is dangerous garbage. A study found it to be remarkably cytotoxic and one can only assume that it's pyrolysis products will Vulcanize one's lungs.
Psychological Drawbacks: Natural alkaloids found in Solanaceae (Datura, Brugmansia, Belladonna, etc.) can be useful precursors, but by themselves are hellish and dangerous. Stimulants, especially the high-powered ones like cocaine, cathinones and amphetamines are not things I ever want to encounter again, simply because the risk of psychosis is so high ["That sounds like a personal problem, Newton2.0"]. I guess, know what your mind can take. Some minds are not built for speed.
Environmental: Remember to safely sequester and dispose of any and all heavy metals like nickel, lead, cadmium and mercury. And anything that could be a persistent environmental problem should probably get a workaround, no?
What are your no-nos?