J. Med. Chem. 43(6), 1215-22 (2000) (https://www.thevespiary.org/rhodium/Rhodium/pdf/cocaine.piperidine-based.analogs.sar-2.pdf)
(https://www.thevespiary.org/rhodium/Rhodium/pdf/cocaine.piperidine-based.analogs.sar-2.pdf)Post 329686 (missing)
(Rhodium: "Precious metals & Crack", General Discourse) and the full ref is found in the doc linked inPost 357128 (missing)
(Rhodium: "Arecocaine", Novel Discourse).Post 444618 (missing)
(Rhodium: "Dopamine Transporter SAR of Tropanes", General Discourse)Post 440396 (missing)
(Rhodium: "Novel Sigma-1/DAT ligands", General Discourse)Post 212069 (https://www.thevespiary.org/talk/index.php?topic=11543.msg21206900#msg21206900)
(monkpea: "Re: Structurally simple cocaine analogs -Beagle", Novel Discourse) that at least one analogue should produce a numbing effect similar to standard cocaine. Does this hold true for all of them?Post 329415 (missing)
(Rhodium: "I feel there are TOO many coincidences now...", General Discourse)?Post 446941 (https://www.thevespiary.org/talk/index.php?topic=12547.msg44694100#msg44694100)
(tropine: "Arecoline analogue...freebase success! But....", Serious Chemistry)J. Org. Chem. 62(22), 7888 - 7889 (1997) (https://www.thevespiary.org/rhodium/Rhodium/pdf/anhydroecgonine.2-tropinone.pdf)
(https://www.thevespiary.org/rhodium/Rhodium/pdf/anhydroecgonine.2-tropinone.pdf)10.1021/jo9710083 (http://dx.doi.org/10.1021/jo9710083)
Post 221796 (missing)
(Rhodium: "Re: 4-fluorophenyl cocaine analog", General Discourse), which is a grignard addition of 4-fluorophenylmagnesium bromide to the formed anhydroecgonine (this article also describes the preparation of anhydroecgonine). Have you performed a grignard reaction before?Post 330321 (missing)
(Rhodium: "Zorro: The yield minus the losses in each step, ...", General Discourse)) also describes the reaction, and tells us that Compound 13, which is the one we are interested in, is approximately 60x more effective than cocaine on a weight basis to induce "locomotor activity" in mice... To read the *.djvu article in the post above, check outPost 330098 (missing)
(Rhodium: "What is DejaVu?", General Discourse)https://www.thevespiary.org/rhodium/Rhodium/pdf/cocaineanalogs.pdf (https://www.thevespiary.org/rhodium/Rhodium/pdf/cocaineanalogs.pdf)
Patent EP604354 (http://l2.espacenet.com/dips/viewer?PN=EP604354&CY=gb&LG=en&DB=EPD)
- but the language is extremely technical.