https://www.thevespiary.org/rhodium/Rhodium/pdf/leuckart.pdf (https://www.thevespiary.org/rhodium/Rhodium/pdf/leuckart.pdf)
) Leuckart reaction review admits that phenylacetones usually gives a 20-70% yield, the substituted ones being in the low end. Don't even think about it.Due to the regulations with the chemical nitroethane, i decided to go about making 2,5-DMA with making 2,5-dimethoxyphenylacetone from 2,5-dimethoxybenzaldehyde with methyl 2-chloropropionate and sodium methoxide, the yeld from this is 14g.
So you got 14g yield? That could be a 0.01% yield, or a 100% yield, for all we know. WTF amount did you start with?
PB
To obtain amphetamines, Leuckart can only be applied on P2Ps, not P2NPs. Furthermore, I have very very high doubts that your 60% yield is a pure substance. In other words, I'm about sure that 50% of your 60% yield consists of useless molecules, most probably condensation products. Unless you show me a chromatogram demonstrating the high purity of your product, I cannot believe you
I am aware that the Leuckert works with ketones not nitroalkenes. The dmp2p in the Leuckert rxn I was talking about was made from dmp2np w/Fe-HCl. The product was purified via standard a/b then vac. distilled. I didn't do a chromatograph or a mp test on the hydrochloride, and I don't really care if you believe me or not. I don't have a reference to back this up; I was simply offering information I know to be correct. IMO this is more valuable than a ref. for a procedure in a journal performed by research chemists, the yields in which are rarely reproducable by an amateur chemist.