Conversion of Indolylalkylhydroxylamines to stimulant amines in vivo.
Lessin, AW.; Long, RF.; Parkes, MW.
Biochemical Pharmacology, 1966, Vol . 15, pp . 481-487.
Abstract:
The stimulant effects due to several indolylalkylhydroxylamines in mice were shown to resemble closely in degree and in time course those of the corresponding indolylalkylamines. The hydroxylamine derivatives were shown to be inactive as inhibitors of monoamine oxidase, and of the uptake of amines in vitro, properties which had been suggested as responsible for the stimulant actions of the amines. Since the tissues of animals treated with the hydroxylamine derivatives were shown to contain the corresponding amine and tissue homogenates incubated with the hydroxylamines rapidly reduced them, it was concluded that the stimulant properties observed were due to the formation of indolylalkylamines in vivo.
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