https://www.thevespiary.org/rhodium/Rhodium/pdf/prodine.pdf (https://www.thevespiary.org/rhodium/Rhodium/pdf/prodine.pdf)
I think the product be something
From alpha-methyl styrene
Alpha-methyl styrene (1-phenyl-1-propene; Benzene, 1-propenyl) and Bromine in 15% sulfuric acid. (51.5% yield). Alpha methyl styrene can be prepared by isomerizing allyl benzene with any of the methods used for isosafrole from safrole. Inoi, Japan 69 09,892 (1969); Chemical Abstracts vol 71, 61016x (1969). Use of the peracid oxidations for isosafrole can also be applied for alpha methyl styrene to yield phenylacetone.
https://www.thevespiary.org/rhodium/Rhodium/chemistry/tcboe/chapter5.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/tcboe/chapter5.html)
http://amorgos.pharm.auth.gr/alexidis/ (http://amorgos.pharm.auth.gr/alexidis/)
confabstracts/abstract1.html.N. Alexidis, E. Rekka, V.J. Demopoulos and P.N. Kourounakis.
Synthesis and protective effect of two new thiol containing compounds against mercuric acetate intoxication.
XIIIth International Symposium on Medicinal Chemistry, Paris 1994, abstract book, P142.
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Abstract
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Mercury has been identified as a highly toxic metal to man. It is well known that inorganic mercury, accumulated predominantly in the kidney, causes oxidative damage to renal tissue mainly in the proximal tubule cells. Furthermore, many data have shown that mercury can promote lipid peroxidation as well as loss of cell viability in isolated hepatocytes. In the present communication the synthesis of two novel thiol containing piperidine derivatives (I and II) and a preliminary study on their action against mercuric acetate intoxication are reported. For the synthesis of the two compounds different routes were followed. For compound I 4-piperidone monohydrate hydrochloride and propyl bromoacetate were reacted to produce n-propyl 4-oxo-piperidine-1-acetate, from which compound I was obtained after reaction with cysteaminum chloride. Compound II was obtained by reaction of cysteaminum chloride and 1-(2-phenylethyl)-4-piperidone, which was synthesized from phenethylamine and methyl acrylate, followed by a Dieckmann condensation and decarboxylation. The structures of the synthesized compounds were supported by spectral data and elemental analyses. The in vivo experiments were carried out in female Fischer 344 rats divided in eight groups, each containing 5-10 animals. Group 1 was given mercuric acetate, 6.2Ìmol/Kg, intraperitoneally once daily for six days. Groups 2, 3 and 4 were given mercuric acetate as in group 1 and compound I (15Ìmol/Kg), compound II (15Ìmol/Kg) and penicillamine (100Ìmol/Kg), subcutaneously, twice a day, for six days, respectively. Groups 5, 6 and 7 were given compound I, compound II and penicillamine as described above. Group 8 was given water intraperitoneally and used as control. The seventh day all animals were anesthesized with ether, blood was collected from the aorta, and liver and kidneys were removed. For the estimation of the cytoprotective activity of these compounds, serum alkaline phosphatase (ALP) and serum alanine aminotransferase (SGPT) were determined, liver and kidneys weight was recorded. From our results it can be concluded that both compounds I and II offer significant protection against mercuric acetate intoxication which is comparable to that offered by penicillamine, at doses much lower than penicillamine. Furthermore, the examined compounds were found to be less toxic than penicillamine as estimated by the parameters determined. The mechanism of this protection is also discussed.