if alpha-ethylstyrene were replaced with anethole and propionc acid replaced with glacial acetic acid in the Prodine synth
https://www.thevespiary.org/rhodium/Rhodium/pdf/prodine.pdf
I think the product be something
like 1,3-dimethyl-4-(4-methoxy-phenyl)-4-acetoxypiperidine. Anyone think it would be active?
In "Future Synthetic Drugs of Abuse" it is stated that a "limited scope of (prodine) derivatives"
have "appreciable analgesic activity." and cites (Berger et al. 1947; Ziering and Lee 1947;
Beckett et al. 1957; Loew and Jester 1975). I dont have access to those articles, but i wonder what they mean by "appreciable". If it takes 500mg to get a buzz and there are no neurotoxic impurities, it would be worth imagining such an easy synth.