The Vespiary

The Hive => Tryptamine Chemistry => Topic started by: pHarmacist on January 30, 2003, 04:47:00 PM

Title: Cobalt-Catalyzed Total Synthesis of (±)-LSD
Post by: pHarmacist on January 30, 2003, 04:47:00 PM

Abstract: Cocyclization of 4-ethynyl-3-indoleacetonitriles with alkynes in the presence of CpCo(CO)₂ gives rise to the ergoline derivatives 6-9, two of which were transformed into racemic lysergene and LSD, respectively.

See full-text at:

http://pharmacist8.tripod.com/ergot.pdf (http://pharmacist8.tripod.com/ergot.pdf)

Reference: Synlett 1994; 487-489

Title: That paper is elegant & beautiful!
Post by: YourMomma7111 on February 03, 2003, 08:35:00 AM

Note that, in conversion from compound 9 to compound 10, one could substitute CF3SO3Et in THF at O degrees Celsius and end up with ETH-LAD (alkyl N-ethylated LSD-025) instead of LSD, which is a much dirtier drug than the former, although on a microgram to microgram scale the two are of about equipotentcies.

Title: Yessiree, went right over my head,
Post by: EtHeRpEeKeR on February 11, 2003, 02:52:00 AM