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3,4 dimethoxy phenethyl alcohol as precursor?

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Starblood:

So are there any good methods for converting 3,4 dimethoxyphenethyl alcohol into good stuff?
I am thinking that the alcohol group would be a big pain to try to modify, any suggestions?

CHEM_GUY:
I think that this would be a very good precursor.

You could slightly oxidize the alcohol into a aldehyde group and then go the Schriff Base route.

3,4-di MeO-C6H3-CH2-CH2OH  +  NaOCl dripped into an acidic medium -->  3,4-di MeO-C6H3-CH2-CH=O

3,4-Di MeO-C6H5-CH2-CH=O  +  NH2R  -->  3,4-Di MeO-C6H5-CH2-CH=NHR  --( H2)-->  3,4-Di MeO-C6H5-CH2-CH2NHR



This post is for informational purposes only an is not intended to facilitate illegal activity.

Rhodium:
This would produce 3,4-dimetoxy-PEA. According to the text at my pharmacology page, this is only active in massive amounts or together with a MAOI.

http://rhodium.lycaeum.org

psyloxy:
if one brominated this, would the Br be on the 2,5 or 6 ?

2 ... useless
5 ... Mescaline or Meta-Escaline
6 ... TMA-2


to make a PEA out of a PhEtOH :
1) R-OH --> R-Br with PBr3
2) R-Br to R-NH2 with NH3 or K-phtalimide


When going to the schiff base, does one use N-hydroxylamine and could one reduce it with NaBH4 to the amine or the hydroxylamine ??

But where would one find this precursor ?

--psyloxy--

Acme:
Oxidize it to the acid; make the weinrab amide. Methyl grignard to the P2P, there you go.

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