The Vespiary

The Hive => Tryptamine Chemistry => Topic started by: java on June 29, 2003, 07:03:00 PM

Title: Concise Large -scale synthesis of Psilocybin and..
Post by: java on June 29, 2003, 07:03:00 PM

Concise Large-Scale Synthesis of Psilocin and Psilocybin, Principal Hallucinogenic Constituents of "Magic Mushroom"
 Osamu Shirota, Wataru Hakamata, and Yukihiro Goda
 J. Nat. Prod.; 2003; ASAP Web Release Date: 30-May-2003;

http://pubs3.acs.org/acs/journals/doilookup?in_doi=10.1021/np030059u (http://pubs3.acs.org/acs/journals/doilookup?in_doi=10.1021/np030059u)

(Note) DOI: 10.1021/np030059u

Title: Large-scale syntheses of Psilocin/Psilocybin
Post by: pHarmacist on June 30, 2003, 04:37:00 AM

Java: I've found that article at about the same time as you did, just saw it! Amazing... Amazing...

However, here is the full-text for those without acsess:

http://pharmacist8.tripod.com/psiloindustrial.pdf (http://pharmacist8.tripod.com/psiloindustrial.pdf)

Abstract: The concise large-scale syntheses of psilocin (1) and psilocybin (2), the principal hallucinogenic constituents of "magic mushroom", were achieved without chromatographic purification. The key step in the synthesis of 2 was the isolation of the dibenzyl-protected intermediate (7) as a zwitterionic derivative (8), which was completely identified by means of 2D NMR analyses.

This is major advance when it comes to synth of psilocybin considering the shitty yield (10%) as presented in TiHKAL for the preparation of the phosphate ester...

Title: Already at my page
Post by: Rhodium on June 30, 2003, 07:04:00 AM

I have uploaded it to

https://www.thevespiary.org/rhodium/Rhodium/pdf/psilocin-psilocybin.large-scale.pdf (https://www.thevespiary.org/rhodium/Rhodium/pdf/psilocin-psilocybin.large-scale.pdf)