The Hive > Tryptamine Chemistry
AMT in the MW oven
Lilienthal:
Sure, it will.
kjb1891:
How good do think the yeilds would be for AET compared to how good the yeilds were for AMT in the MW method?
Rhodium:
Important:
The microwave procedure above does not produce AMT directly, but rather the nitroalkene precursor (3-Indolyl-2-nitropropene) which can be reduced to AMT using LiAlH4 or any other known method.
indole_amine:
And with 1-nitropropane, the intermediate/precursor substance is called 1-(indol-3-yl)-2-nitrobut-2-ene.
But the yield with 1-nitropropane will not be even half as high as when nitroethane is used in above condensation. Reason: 1-nitropropane is too long of a molecule, it can result in two different condensation products, and only one of these is the wanted one... :(
Oh, and there is a thread by Starlight out there, dealing with exactly this type of compound and exactly this type of reaction, too - I quoted the procedure whole seven posts earlier (Post 533225 (indole_amine: "hmm", Tryptamine Chemistry)... ;)
indole_amine
indole_amine:
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