The Hive > Tryptamine Chemistry

IAA --> AET

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psyloxy:
Everyone knows that PAA can be turned into P2P with Ac2O.
So why couldn't one use IAA (indole-CH2-COOH) and propionic anhydrite to make "AET-P2P" ?

"Amphetamine Syntheses" (O.Snow) indicates that the PAA --> P2P rxn gives yields as high as 80%. I don't think they are that high. Anyways, IAA is relatively easy to aquire and 'cheap'.

The rxn is also relatively easy and 'fool proof' IMO. This would be 2 simple steps from plant growth hormone to the MDMA of the tryptamine family.

waddayathink ?

--psyloxy--

Rhodium:
Yes, it is possible that it could work. As IAA is relatively expensive, one should use a LARGE excess of propionic anhydride (note spelling). But - unfortunately for US bees, propionic anhydride is a watched chemical with a treshold of a few grams (noone asks any questions about it in europe though).

http://rhodium.lycaeum.org

phaidon:
Uh, that sounds good! Congrats, psyloxy, wir anderen sind mal wieder blind wie die
Fische rumgelaufen. This is a nice reaction and definately worth trying out, uh,
sorry, dream it out, that is.

Rhodium, you sure Pr Anh is not watched in Europe?

Laters,

-- phaidon, son of apollon

I scorched the Earth, now what do I do tomorrow?

Rhodium:
I am very positive. A friend of mine ordered 500ml from aldrich about a year ago, and there were no questions asked, which really impressed him.
The reason it is watched in the US is because of its use in the manufacture of fentanyl derivatives, and I have yet to hear of any clandestine european labs synthing any opioids at all. Its all amphetamines over here.

Nicht vergessen dass die Deutsche sprache hier verboten ist, die Amerikanische Leute können verwirrt werden, ganz als meine Deutsche grammatik.

http://rhodium.lycaeum.org

psyloxy:
Hm, I think it wouldn't be that a problem to make propionic anhydride [thanks for your spelling tips] from propionic acid. For IAA: I think I have read somewhere that one could make indole-3-acetaldehyde from tryptophan. Me thinks if one would use a stronger oxidizing agent one would get IAA.

--psyloxy--

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