Yes it will be a mix of every subs position with bromo but a mix of 4 & 5 are ok to use further on so its just eh other % you need to get rid of.... which are only small
i didnt want to decarbox asprin to phenol i wanted to get to dihydroxy... unless you can buy them phenol straight up and add another OH group ortho... how to dercarbox and leave an OH group in its place was what i was asking....
Sorry i didnt read properly... i put the (?) for #3 because i didnt have refs i was wondering how it could be done.... the brackets for the other steps contain info i know how to and were included to give an idea of process.
are you talking about myconcerns #3??? i was talking about replacing the bromination step with an addition of chloroacetone so the end product would be MDP2P instead, as i said, it would be a dream....
Or are you talking about my reply?
NBS - N-bromosuccinamide (sp?) its on rhodiums synth page for catchetol --> safrole.
If you leave out the bromination step and just go ahead and methylate the dihydroxybenzene you can just use HBr and AlCl3 to brominate the ring in major yields... the methoxy groups are ortho/para directing, ortho is the major product but the para would be fine (i think para in this system end up ~20% of the yield???.
2,5-DMA looks budget anyway as per:
http://www.erowid.org/library/books_online/pihkal/pihkal054.shtml
So i would rather not end up with this....
Crap, i dont think this is really going anywhere, much the same as my failed thought about grinards --> ghb...
Oh well, leave the asprin on the shelf where it should be i guess....
-AC