http://www.chem.ubc.ca/courseware/121/tutorials/exp3A/columnchrom/ (http://www.chem.ubc.ca/courseware/121/tutorials/exp3A/columnchrom/)
You do not have to extract the pfed and clean it up like people are doing it now. You only need to extract as much of the pfed as possible. Contaminants will not matter since they will be removed during chromatography. The extract may contain pfed and all the gakks, chromatography will nevertheless clean it up
No shit! I was saying the exact same thing, I meant to only do a rough extraction, or else why would you even need to chromatograph?
You also do not need to achieve good separation between the individual pill components. All we want is the pfed, all the other crap doesn't need to be separated from each other. It won't matter if the other components will end up with an Rf of either 0 or 1, as long as the pfed is in the Rf=0.1-0.9 range.
I KNOW GODDAMNITT! I said you have to adjust the tlc plates at first until you get good separation (on the plates), then use a reagent to identify each spot to find out which is pseudo, then adjust until your pseudos spot has Rf of .5. I got that from here:
https://www.thevespiary.org/rhodium/Rhodium/chemistry/equipment/flashpad.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/equipment/flashpad.html)
Also, people should NOT do columns (well, maybe once or twice, for learning purposes). There is a much easier method on Rhodium's, which uses a buchner funnel and a filtration flask. This method is MUCH more economical since it uses way less SiO2 (or other absorbent) and solvents, and it's also much faster to perform.
Again follow the link above and you'll see the flashpad thing is what I was referring to all along. I've read that whole section at Rhodiums at least 100 times (along with probably the rest of the damn page, I've been going to Rhodiums for several years now).
I know my writing may be a little hard to understand or decipher sometimes, and I know it was a long post, but you should actually read them next time instead of skimming and then attacking my credibility.
If you think it's so pratical, what ideas have you got? Seriously, I am interested, cause this is a good direction to lean toward for pill extraction. Is there an easier way?
First, you'd have to extract the pseudo as best as you can anyway using conventional methods because in raw pill mass there is just way to many chemicals in there to be separated.
It may have been a little misleading. I wrote that in mind however, thinking of the methods used in the past on the pills SWIM used to use, which will yeild gakked crap on the ones with the new gaks upon extraction. I simply meant that sometimes some simple procedures people DO still use now, should be ran still, and the separation is to be done using this.
https://www.thevespiary.org/rhodium/Rhodium/chemistry/equipment/flashpad.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/equipment/flashpad.html)
J. Chem. Educ. 74, 1222-1223 (1997) (https://www.thevespiary.org/rhodium/Rhodium/chemistry/equipment/dry-column.flash.chromatography.html)
(https://www.thevespiary.org/rhodium/Rhodium/chemistry/equipment/dry-column.flash.chromatography.html)Synthesis 2431-2434 (2001) (https://www.thevespiary.org/rhodium/Rhodium/chemistry/equipment/dry-column.vacuum.chromatography.html)
(https://www.thevespiary.org/rhodium/Rhodium/chemistry/equipment/dry-column.vacuum.chromatography.html)http://www.geocities.com/dcarrd2000/columchrom.html (http://www.geocities.com/dcarrd2000/columchrom.html)
http://nas.cl.uh.edu/sanchez/CHROMATOGRAPHY.doc (http://nas.cl.uh.edu/sanchez/CHROMATOGRAPHY.doc)
http://orgchem.colorado.edu/experiments/idunk/idunklabcolchrom.html (http://orgchem.colorado.edu/experiments/idunk/idunklabcolchrom.html)
Detailed with pics.