I have a few question concerning the borohydride reductions.
First I have UTFSE and couldn't find any definitive information on using methylamine hcl in the sodium borohydride reduction, but I did find info on sodium cyanoborohydride and sodium triacetoxyborohydride so it appers that methylamine hcl use is pretty common with both of these reactants. Now has anyone ever used methylamine hcl with sodium borohydride or heard of anyone using it, or experience with it? My second question is concerning the sodium borohydride addition, once you have imine formation, the addition goes much slower than with cyano or triacetoxy, can anyone explaine this to me? BTW Barium's benzaldehydes to phenylacetones works great, gonna try asarone to asaraldehyde to TMP2P next