Post 122784 (https://www.thevespiary.org/talk/index.php?topic=12400.msg12278400#msg12278400)
(dormouse: "Bromo-benzodifuranyl-isopropylamine -Lilienthal", Serious Chemistry). I know that humans are virtually unable to metabolize Trifluoromethyl groups, apperently it just won't leave the receptor? Its ridiculously electronegative, And still very hydrophobic -- it CAN'T hydrogen bond to anything. No enzyme can bind to it. As Dr. Shulgin put it "its the world's shortest length of teflon", and essentially that is what it is. (To borrow a few word's from Drone)J. Med. Chem. 44, 2001, 1003-1010 (https://www.thevespiary.org/rhodium/Rhodium/pdf/nichols/nichols-dragonfly-2.pdf)
(https://www.thevespiary.org/rhodium/Rhodium/pdf/nichols/nichols-dragonfly-2.pdf)J. Med. Chem. 41, 1998, 5148-5149 (https://www.thevespiary.org/rhodium/Rhodium/pdf/nichols/nichols-dragonfly-1.pdf)
(https://www.thevespiary.org/rhodium/Rhodium/pdf/nichols/nichols-dragonfly-1.pdf)J. Med. Chem. 39, 1996, 2953-2961 (https://www.thevespiary.org/rhodium/Rhodium/pdf/nichols/nichols-dihydrobenzofuran-3-fly.pdf)
(https://www.thevespiary.org/rhodium/Rhodium/pdf/nichols/nichols-dihydrobenzofuran-3-fly.pdf)Post 108811 (https://www.thevespiary.org/talk/index.php?topic=11960.msg10881100#msg10881100)
(dormouse: "Thiocyanation of 2C-H -Rhodium", Novel Discourse)[...] And the first indicators are that, in keeping the 2,6-dimethoxy aspect intact, a completely analogous series could be made, again with modifications of the 4-position. These have been named the psu-series, or psi-series, as an abbreviation for the prefix, pseudo,
and can be differentiated from the 2,4,5-things with the use of the Greek letter "gamma". Thus there is the gamma-DOM (called Z-7 in this book, and certainly an active compound), and gamma-DOB, gamma-DOET, gamma-DOI, and the gamma-ALEPH compounds. And, of course, the gamma-2C-X counterparts. I would expect all of them to be active and, certainly, some of them interesting. They will be considerably more difficult to synthesize. However, some of them, specifically things such as gamma-2C-T-4, have already been prepared, and are being evaluated.
J. Med. Chem. 27(4), 513-520 (1984) (https://www.thevespiary.org/rhodium/Rhodium/pdf/2c-c.2c-cn.synthesis.pdf)
(https://www.thevespiary.org/rhodium/Rhodium/pdf/2c-c.2c-cn.synthesis.pdf)Post 228277 (https://www.thevespiary.org/talk/index.php?topic=9944.msg22827700#msg22827700)
(slappy: "Re: J Med Chem Paper with DOB-like phenethylamine", Methods Discourse)J. Chem. Soc. Perkin Trans. 1. 841-848 (1982) (https://www.thevespiary.org/rhodium/Rhodium/pdf/dihydrobenzofurans.mannich.pdf)
(https://www.thevespiary.org/rhodium/Rhodium/pdf/dihydrobenzofurans.mannich.pdf)Post 229163 (https://www.thevespiary.org/talk/index.php?topic=9944.msg22916300#msg22916300)
(megamole: "Re: J Med Chem Paper with DOB-like phenethylamine", Methods Discourse). I hope you'll enjoy it.(https://www.thevespiary.org/rhodium/Rhodium/hive/hiveboard/picproxie_imgs/pdf.gif)