SWIM's friend just started working at a health food store that is ordering in some absolutely pure vanilla powder so SWIM is looking for the best otc way to make some goodies. I've read a bunch of stuff about this from rhodium's and elsewhere but would like to ask if anyone here has some practical experience with these kind of procedures. A few questions;
1. If you take the vanillin and react it with nitromethane and ammonium acetate, then reduce with Hcl/Zn or Al/Hg to get an amine would the OH on the ring cause any problems or solubility differences from common ways to isolate amphetamines.
2. Should you then react with dimethyl sulphate or should you first brominate the 3-position.
So the sequence of events might look like;
1. react vanillin with nitromethane and amacetate.
2. reduce the nitro to a PEA with Zn/HCl or Al/Hg.
3. react the PEA with dimethyl sulphate to get your 4,5-dimethoxyPEA.
4. Brominate the 3-positon with bromine and GAA.
5. reflux in NaOH to get the 3-hydroxy-4,5-methoxyPEA.
6. React with dimethyl sulphate to get your 3,4,5-trimethoxyphenethylamine.
Is SWIM on the right track here or is this messed up?
This seems to be a totally otc route to mescaline if it would work.
Any suggestions would be very much appriciated.
-improv
Let's play with nature a little, I'm sure we can make her a little higher....