Ok so since swid finally spelt the shit right he comes upon a post discussing the us of ethanolamine to hydrolyze. Swid is ever hesitant to go charging ahead without a layed out synthesis. Vibrating lights posted this workup in
Post 404393
(Vibrating_Lights: "Will the ring of the phlactamide group also...", Chemistry Discourse)15 gms(.048m) of N-(2-(2,5 Dimethoxyphenyl)ethyl)phthalimide is placed into 50ml MEOH with 1.02gms(.01m)KBr. Then the solution is stirred while .01m of Oxone(aq) is added. The solution is stirred till completeion. 2ml of (aq)Sodiumbisulfite is added then the rxn is basified with 25%NaOH and extracted 3x50ml of DCM. Dcm extracts are washed with Bisulfate again then once with NaHCO2. The Dcm is removed under vaccume to give N-(2-(4
bromo-2,5-Dimethoxyphenyl)ethyl)phthalimide. (.048m) 15 gms N-(2-(4 Bromo-2,5-Dimethoxyphenyl)ethyl)phthalimide Is refluxed in ethanolamine for 20 mins. Then the rxn is flooded with water. The amine is extractred with 3x50ml of dcm and the residue distilled under N2 to give 2CB. 2CB freebase is then treated with .045m of 20% HCL.
Ok well this is a somewhat experimental workup. If the above indeed sounds good, what amount of ethanolamine would you bees suggest? Does the above sound good to more experienced bee's? Also does anybody that has tried making 2CH or halogenated phenethylamine using this route(with ethanolamine) have any suggestions for a less experienced bee?
Swids friend has few hundred g's of the N-(2-(2,5 Dimethoxyphenyl)ethyl)phthalimide coming next week. There is no turning back now without losing money out the ass. If swid can post a success with this project then ANYBODY who is semi competant will be assured success. Will post results, when results are known.
Many thanks