this (https://www.thevespiary.org/rhodium/Rhodium/chemistry/meth-nabh4.html)
(https://www.thevespiary.org/rhodium/Rhodium/chemistry/meth-nabh4.html) document, labtop describes an reductive amination of P2P using methylamine and borohydride in methanol.Post 458857 (https://www.thevespiary.org/talk/index.php?topic=11864.msg45885700#msg45885700)
(Barium: "Improved "wet" reductive alkylation", Novel Discourse)Post 503533 (https://www.thevespiary.org/talk/index.php?topic=9774.msg50353300#msg50353300)
(Bandil: "Pseudo-"wet"- BH4 amination BH4", Methods Discourse)The reaction is so suitably slow, that all the borohydride1 can be added in one portion
Hi Bandil,
SWIM is trying to get his amination working correctly, and would like to get the sam yield as you.
In the above statement, what was the temperature that you encountered? Did it go near to IPA's boiling point?
And, did you just add the pallets/powder into the IPA solution?
What was the largest rxn that you have tried with no problem adding NaBH4 in 1 go? Can 5 mol scale be used and still add the NaBH4 in 1 go? :-[