Hey I have a reference here that gives highly selective bromination in trifluoroacetic acid.
Is that better?
I for one am very interested in that!
SpicyBrown
All the halogenated solvents works fine
- you mean, with NBS or with bromine as well? What conditions - like temp?
Please, bee a little more specific! :-[ - ahh, why all you really cool chemists are so tough to get talking! :)
Sorry if i'm bugging you...
But, see, your experience is so important - noone else seems to have done it on this board...
Antoncho
highly selective bromination in trifluoroacetic acid.
trifluoroacetic acid usage as catalysator in epoxidation. It's a bit expensive to bee used as a sovesnt, isn't it?
It could be interesting a direct bromination in DCM, but the question is if the amine group would be affected and/or bromination occurs exclusively in 4 position.
Well, haven' t done it but I'm damm sure it will brominate solo in the 4 potition, and the amine will not affect it.