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The Hive => Chemistry Discourse => Topic started by: psyloxy on May 07, 2004, 09:04:00 PM

Title: CuCl/CuCl2/I2 a-iodination of propanoic acid - 90%
Post by: psyloxy on May 07, 2004, 09:04:00 PM

(https://www.thevespiary.org/rhodium/Rhodium/hive/hiveboard/picproxie_imgs/djvu.gif)

chem.lett. - 1984 - 1509/1510

alpha iodopropanoic acid (brief summary, read the 2 page .djvu!)

CuCl (0.5 mol equiv), CuCl2 (0.5 mol equiv), I2(1 mol equiv) and propanoic acid (excess) are mixed and reacted at 120°C for 6h under N2 atmosphere. Precipitated copper salts are filtered, excess acid is distilled off, product is recrystallized from hexane to afford a 90% yield based on I2.


where to go from here ?

Post 212002 (https://www.thevespiary.org/talk/index.php?topic=9255.msg21200200#msg21200200)

(Rhodium: "Easy nitroethane in quantitative yield", Methods Discourse)

Post 333551 (https://www.thevespiary.org/talk/index.php?topic=11449.msg33355100#msg33355100)

(Barium: "benzaldehydes to phenylacetones", Novel Discourse) w/the corresponding alkyl esters; prep. of methyl ester: J.Org.Chem.; 45; 14; 1980; 2831-2834.

--psyloxy--
Title: Nice find!
Post by: moo on May 09, 2004, 10:29:00 PM
Nice find!