Thanks to nicodem for his constructive critic.
Its like i said:
The mentioned chemicals are easiely obtainable in germany.
2 days ago a friend asked me to give him an easy procedure to yield P2P. (i know that he have to learn much in preparative chemistry so i decided to keep it easy and untoxic) I remembered a kondensation like this from my first semester in organic chemistry where piperidin was used as a katalysator.
But now i´m confused. I´ve read lots of posts and hypothetical methods which yields are much lower as 50%.
Even at rhodium methods can be found which are
1. hypothetical
2. low yielding
3. complicated
btw organic chemistry is not my building site. i´m specialized in anorganic chemistry and drug syntheses is only a little hobby for me.
Selfcritic:
This method is hypothetical and not proofed, but possible.
Other solvents like alkohol are possible but contraproduktive in this reaktion because an alkohol creates and must be deleted from the reaktion mixture.
Alkohols possibly form s a aceotrop with aceticacidmethylester and could be destilled off. (possible!! not proofed)
As katalyst we need a strong base, which isnt nucleophile.
Piperidin or NEt3 could be used. (possible! not proofed)
Every student learns to take NaOEt, Na or sodiumamides as katalyst in claisen kondensations. But is this a must ?
This method can be improoved if u are able to obtain LDA (Lithium di isoproyl amin). Ill bet yields could be very high.
P.S. If a compound calls a nitril or cyanide it definetly contains a CN functional group. Compounds like these havn´t to be toxic or noxious but can evolve HCN if they are treated with strong acids. It is my job to handle compounds like these every day. I dont wanna make P2P (can buy it from every ordenary chemical supplier).
But now imagine a bee and think about murphys law.
Cant make anything idiot-proof.
The idiots are too imaginative.
In relation to improoved Claisen kondensations:
Why do u want to use CN-compound,which makes the a more acidic, if u can take a NO2-compound, where the a is much more acidic
?