The Vespiary

The Hive => Chemistry Discourse => Topic started by: Flip on August 12, 2002, 09:11:00 PM

Title: MP-NEt3BH4 in place of NaBH4 for reductions
Post by: Flip on August 12, 2002, 09:11:00 PM

Is there any reason that one could not use macroporous triethylammonium methylpolystyrene borohydride in place of NaBH₄ for reductive amination?

I'm sure the DEA would rather skip it than waste an entire breath asking me why the fuck I would order macroporous triethylammonium methylpolystyrene borohydride

http://www.argotech.com/PDF/resins/mp_borohydride.pdf (http://www.argotech.com/PDF/resins/mp_borohydride.pdf)

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"I like you, but I wouldn't want to see you working with subatomic particles."

Title: Should work fine.
Post by: terbium on August 12, 2002, 10:45:00 PM

This product should work fine for the reduction of methylimines. The only negative is that it is bulky - about 300 grams per mole of BH₄.

Title: Re: 'Should work fine.'
Post by: Flip on August 12, 2002, 11:20:00 PM

Thanks,
I suspected as much but I am never 100% with anything for lack of an official education.  Been dreaming on reductions and borohydride substitutes came to mind.  I know this one is a little obscure.  I'm learning though.  I'm not sure how much this shit costs but even an inconvienient substitute is a good one, and sometimes a good precaution, when your own name is on the order form.

Flip

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"I like you, but I wouldn't want to see you working with subatomic particles."