There are a pile of refs that parallel the reaction with varied levels of success. I thought it would be worth a shot.
I noticed the hive problems. Posted wild variations in reaction times, reactant ratios, pressures and agitation methods didnt dampen my spirit.
Just to double check, so The Hive Collective is saying that dmf/o2, meoh/o2, ipa/o2, krv and osmium variations are all bullshit?
I seem to remember that PdCl2 doesnt disolve in ipa very well, which led me to question those posts. Mechanical stirring has never worked well for me in hydrogenations, so I had no problem believing the mag stirring failures.
Now SWIST was planning on running small scale dmf, ipa/meoh and meoh at 2 to 4 atm, monitoring o2 uptake, temp and tlc to get to the bottom of this. Was going to start with the ratios for the dmf wacker from rhods site by krz and grouch at 2.5atm. SWIST thinks they are using too much solvent and cucl2. SWIST was also going to run a 200ml meoh/1gPdCl2/5gCuCl2hyd starting at 3 atm and no heat for shits and giggles. SWIST was planning on also running meoh/ipa mixes.
If these have been unrepeatable, why are they on rhods site and here? What about the refs? Wacker oxidations are not new.