Some recent applications of Amino Nitrile Chemisty

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Some Recent Applications of -Amino Nitrile Chemisty

Chem. Soc. Rev., 29 (5), 359-373 (2000)

(http://www.rsc.org/CFmuscat/intermediate_abstract.cfm?FURL=/ej/CS/2000/a908290e.PDF&TYP=)
DOI:

10.1039/a908290e

Abstract

Bifunctional -amino nitriles are not only versatile intermediates in organic synthesis but also exhibit a valuable dual reactivity, which has been utilized in a broad range of synthetic applications. This review highlights recent developments in the chemistry of -amino nitriles, including asymmetric synthesis of -amino acids via Strecker reactions using chiral auxiliaries and catalysts, -amino nitriles as masked iminium ion equivalents in cationic reactions and the synthesis of natural products and heterocycles, and -metallation to provide nucleophilic acyl anion equivalents and applications to asymmetric Umpolung reactions.

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Were you thinking of any specific applications of this substance class, or did you just want to share the free review?

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In the (Scheme 26 )Summary of reactions of lithiated a-amino nitriles.

Notice that the production of P2P ketone  and diketones in the reaction with lithiated amino nitriles, that cought my eye and could be exploited say using a cheap OTC Phenylalanine  amino acid.......java