...the pesky problem of not being able to make rational connections and think logically while stoned...
Could you elaborate slightly?
Of course. It affects everyone differently, some (but not all) variables include:
- Present adrenal condition(as this affects cognitve function); hypo/hyper active adrenals, Parkinsons's, adrenal exhaustion, adrenal hysteria (induced by a stressful lifestyle and/or chronic use of marijuana. If not kept in check, will lead to adrenal exaustion), etc.
- Baseline intellectual ability. You see, if most of what you think about hardly stresses your ability to compute then how would you know if your capacity was diminished slightly as it would not require much more effert anyhow. For those whith less than superb intelligence, the wrath is felt much stronger.
- Amino acid consumption and balance. Eating enough protein?
- Tolerance.
- Health, generally.
Now, for the L-Glutamine, one with a greater deficiency would see a greater benefit from supplementaion. If you eat healthfully and consume adequate amounts of whole proteins, then you probably do not have such a noted loss of intellect. For cognitave function under any circumstances, vinpocetine (cerebro vasodilater, derived from periwinle) has been noted to markedly increase information processing speed and attention span.
This includes phosphatidylserine (the chemical connection between your adrenals and brain)...
Oooh... got any further detail on the finer points of 'connection,' perchance?
hmm.. lets see what we can do for ya...
...ahh yes! I owe many thanks to this book about adrenal exhaustion and how to undo it.
Hanley, Jesse, M.D., and Nancy Deville. Tired of Being Tired. The Berkley Book Publishing Group, 2002.
"Phosphatidylserine, which is a brain nutrient, helps rebalance pituitary/adrenal communication and nourishes and supports adrenals while you rest. For those who suffer from insomnia because their adrenals are turning on innapropriately at night, PS can help. You know this happening when you routinely awake in the middle of the night once, twice, or more times a night. You may experience your heart beating rapidly and/or you have to get up and go to the bathroom all night long. PS influences your brain's messages to your adrenals so that they stop the innapropriate release of adrenaline, cortisol and DHEA."
Well activation of the hypothalamic-pituitary-adrenal axis is not the only thing PS modulates.
from
http://www.thorne.com/pdf/journal/1-2/phosphatidylserine.pdf
Abstract Working in the cell membrane milieu, phosphatidylserine (PS) is a nutrient that supports membrane proteins crucial for homeostasis, maintenance, and specialized cell functions. PS is found most concentrated in the brain, where its relative abundance reflects its involvement in specialized nerve cell functions such as chemical transmitter production and release, receptor action, and synaptic activity. The fundamental contributions of PS to the structure and function of individual nerve cells are expressed in the performance of the brain as a whole. More than 35 human studies that span almost 3 decades, together with numerous animal studies, indicate PS supports EEG integration, the HPAA (hypothalamic-pituitary-adrenal axis), and circadian rhythms of hormone release. Some sixteen clinical trials indicate that PS benefits measurable cognitive functions which tend to decline with age; these include memory, learning, vocabulary skills and concentration, as well as mood, alertness, and sociability. PS is a phospholipid, ubiquitous in membranes and obligatory for all the cells of the body. Present in common foods in small amounts, PS may be a semi-essential nutrient. Although it can be synthesized in vivo from precursors, its multistep biosynthesis is energetically costly. Until recently, supplemental PS was available only from bovine brain. Now PS is available as a soy lecithin-based concentrate. With its proven benefits against agerelated mental decline, phosphatidylserine might represent a truly safe and effective means for improving the quality of life of the elderly. (Alt Med Rev 1996;1(2):70-84) The progressive loss of mental agility with age has become a major focus of basic and clinical research efforts. Beginning around midlife, the brain’s higher functions of memory, learning, semantic manipulation, and concentration (collectively referred to as cognition) measurably begin to fade. The ancient writer Virgil put it best in 70 B.C.: “Age takes away all things, even the mind.” An impressive body of human studies with PS, published over a span of almost 3 decades,1-35 now makes possible an optimistic approach to conserving those brain functions that decline with age.
...a timed release pantothenic acid (food for the adrenals) pill.
Eh... at the level of... which... PEA beta-hydroxylase, or...?
I will have to get back to you on the specifics of what enzymes systems are affected by B-5.
This will ensure that the adrenal reserves do not become depleted and lead to irratibilty...
...I've always personally associated that specific with the pre-adrenal, namely dopamine, ever since my lobelidine-group days...
...lack of energy and a fucked up sleep/wake cycle sucks, though...
Dopamine supplementation would downregulate dopamine receptors, IMHO. This would result in a worse feeling when you ceased supplementation than when you started it. B-5 as I have stated, is a nutrient for the adrenals and nourishes them, facilitating their normal functions. On the contrary, adminsitration of DHEA or any catecholamine will in a sense, replace the adrenal functions, facilitating atrophy and Parkinsonism. Catacholamine abuse will rapidly deteriorate the adrenals. First hysteria, then depletion, then exhaustion, then your fucked and you do not want to go on anymore, problems seem worse and worse...
Interestingly enough, my adrenals were completely fucked from wrestling endurance practices and fasting to lose weight. It forced me to think more about things b/c I almost died and recovered very slowly, which forced me to launch an investigation of my own physiology. This investigation after many fruitless leads, came to adrenal exhaustion. So I followed some rejuvenation guidelines and everything just kept getting better.
Well, that's it for now. I can most likely dig up much more information upon request.