Osmium
Member posted 12-21-98 04:12 AM
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Drone: "I'll post ref's if anyones cares for them."
Of course we do. You know that. Want me to say PLEEZE again?
Lilienthal
Member posted 12-21-98 05:30 AM
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Takahashi (Chem. Pharm. Bull. 34, 2071 1986) only gave this short remark and analgesic activities (acid writhing, mice).
Ghosh (Arzneim.-Forschg. / Drug. Res. 28, 1561 1978) found a decrease in motor activity (d-amphetamine gave a strong increase, it's the classical stimulants test). But they used the racemate at 1/10 lethal dose. Maybe it's the opioid (or another, who knows?) activity which dominates at higher doses or with the stereoisomers.
drone 342
Member posted 12-21-98 01:06 PM
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I don't have my ref's with me, but a few of them for 2-benzhydryl-1-methyl-piperidine are:
Helv.Chim.Acta; 37; 1954; 2133,2142,2143;
JACS; 117; 45; 1995; 11124-11133;
CA 57; 2197d; 1962;
JACS; 118; 16; 1996; 3862-3868;
These are some potent analogs, but I know there are ones out there that leave even these ones in the dust. When I remember to bring them, I'll send y'all thei page nubmers, etc. Still from this you should be able get enough info to keep you plenty busy.
-drone #342
I ca
drone 342
Member posted 12-21-98 01:08 PM
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I think the following ref should also be of interest: JMC; 11; 4; 1968; 792-796
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