The Vespiary
The Hive => Novel Discourse => Topic started by: indole on August 09, 2001, 04:07:00 AM
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I UTFSE and could not find anything specifically along these lines:
Can the boiling decarboxylation used to go from tryptophan to tryptamine be used to go from PA to phenylethylamine?
If so:
Could alpha-methyl-PA be decarboxylated to amp?
AND
could alpha-methyl-DOPA be decarboxylated to 3,4-dihydroxy-amp, and easily be methylenated(sp) to mda?
amines to an end
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The answer to the first questions should be yes, and I believe there is some info on this at my page. On the third question, I think that the Methyl-DOPA molecule is to fragile to survive a decarboxylation.
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Could the methylenation occur prior to the decarboxylation?
If so, would that withstand decarboxylation?
On another note, Shulgin stated methylenedioxy-phenylethylamine had no effect. Would this be because it was broken down before the blood/brain barrier? If so,
MD-PA should pass through and be decarboxylated, like L-DOPA, possibly having action?!?!?!
Sorry, I am just so full of questions and so few answers...
amines to an end
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I believe that the amine group would interfer with a methylenation reaction, so that would be hard.
3,4-MD-PEA is probably very readily broken down by MAO enzymes, and it is also probably of very low potency even if taken with a MAOI. There are reports on my page of 3,4-dimethoxy-PEA being active at 500mg together with a MAOI.