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The Hive => Novel Discourse => Topic started by: bottleneck on August 23, 2002, 12:05:00 PM

Title: Allylbenzene to amphetamine with lithium amides
Post by: bottleneck on August 23, 2002, 12:05:00 PM
Hi,


I don't know if everybody knows about this already. In the articles they made a lithium amide from n-BuLi and an amine, and react it with an allylbenzene in a pressure-reactor.




Hartung et al.
"A Base-Catalyzed Domino-Isomerization-Hydroamination Reaction - A New Synthetic Route to Amphetamines."
Tetrahedron vol. 56, no. 29, 14. July 2000, pp. 5157-62
DOI:

10.1016/S0040-4020(00)00436-1 (http://dx.doi.org/10.1016/S0040%2D4020%2800%2900436%2D1)


Post 465442 (https://www.thevespiary.org/talk/index.php?topic=7569.msg46544200#msg46544200)

(Rhodium: "Hydroamination Route to Amphetamines", Chemistry Discourse)


Seijas et al.
"Synthesis of beta-Phenylethylamines from Styrene Derivatives."
Tetrahedron Letters, vol. 39, no. 28, 9. July 1998, pp. 5073-6
DOI:

10.1016/S0040-4039(98)00907-1 (http://dx.doi.org/10.1016/S0040%2D4039%2898%2900907%2D1)


Post 465452 (https://www.thevespiary.org/talk/index.php?topic=7569.msg46545200#msg46545200)

(Rhodium: "beta-Phenylethylamines From Styrenes", Chemistry Discourse)


Beller et al.
"Base-Catalyzed Hydroamination of Aromatic Olefins - An Efficient Route to 1-Aryl-4-(arylethyl)piperazines."
Tetrahedron vol. 54, no. 23, 4. June 1998, pp. 6359-68
DOI:

10.1016/S0040-4020(98)00295-6 (http://dx.doi.org/10.1016/S0040%2D4020%2898%2900295%2D6)