Sumatriptan is a sulfonated tryptamine NEARLY analagous in form to DMT. Has anyone ever come across a proposed mechanism for the reduction of sumatriptan to DMT? After all, sumatriptan contains DMT in full form! A DESULFONATION AND A DEMETHYLATION WOULD MOST LIKELY DO THE TRICK. Does anyone have any further references or ideas? Check out the sumatriptan link:
http://us.gsk.com/products/assets/us_imitrex_nasal_spray.pdf (http://us.gsk.com/products/assets/us_imitrex_nasal_spray.pdf)
-PB
What part of the methanesulonamide chain would act as the leaving group? Could the entire chain be cleaved in one reaction?
Pricewise, you can get about 1 gram of sumatriptan accompanied by the succinate salt for whatever the cost of your copay is (assuming that you have prescription insurance)in the 100mg Imitrex tablets. If you've got a good doctor you could probably get plenty of samples for free! Here's another link to the structure of sumatriptan: http://www.ajdesign.com/Elliott/Migran.htm (http://www.ajdesign.com/Elliott/Migran.htm)