The Vespiary
The Hive => Chemistry Discourse => Topic started by: Alkylight on August 15, 2001, 04:31:00 PM
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Does anyone know if there is any scope for the developement of new drugs using solid phase chemistry. I was thinking of anchoring the basic amphetamine subunit to the solid phase using a linker known as the 'bromo WANG' linker. Basically just a resin bound benzylbromide. I have a bit of experience with solid phase organic chemistry. I have been playing with this idea for a little while now and I was wondering if it has any worth. Could a whole new library of say amphetamine type drugs be built up this way??
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General Combinatorial Synthesis of Tertiary Amines on Solid Support.
Tetrahedron letters
42 (2001) 133-136
This is more applicable to some tryptamine goodies.
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