Does anyone know anything about the precursors mentioned on https://www.thevespiary.org/rhodium/Rhodium/chemistry/levorphanol.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/levorphanol.html)
for making levophanol/racemorphan?
Especially:
2-(1,4-Cyclohexadienyl)ethylamine
and
p-Methoxyphenylacetyl chloride
I cannot find any information on these, do they have any other names? Any info on synthesis of these would be greatly appreciated!
The first one is made though birch reduction of 2-phenetylamine, and the second through chlorination of 4-methoxyphenylacetic acid with SOCl2. One synthesis of the latter precursor can be found at https://www.thevespiary.org/rhodium/Rhodium/chemistry/willgerodt.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/willgerodt.html)
but there are others.
If you have the necessary equipment to perform the above reactions I'll help you further.