Author Topic: PTC Willgerodt synthesis of Phenylacetic Acid  (Read 1485 times)

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Rhodium

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PTC Willgerodt synthesis of Phenylacetic Acid
« on: March 09, 2003, 12:09:00 PM »
Abstract

Phenylacetic acids are efficiently synthesized from acetophenones via thiomorpholides under Phase Transfer Catalytic (PTC) condition. The reaction proceeds efficiently by using triethyl benzyl ammonium chloride (TEBA) as PTC and the reaction time decreased dramatically up to 1/5th to afford pure products in good to excellent yield.



Synthetic Communications 33(1), 59-63 (2003)

(https://www.thevespiary.org/rhodium/Rhodium/chemistry/willgerodt.ptc.html)