Experimental procedures:
28,2(150 mmol) g (-/+)-norephedrine was dissolved in 141 mL's tap water at rt. in a 500 mL FB. erlenmeyer flask.
The whole lot dissolved without any problems. Next 12,0 g of KOCN was dumped into this soln. No heat evolution was noted. With some stirring with a mag bar, 75% of the KOCN dissovled.
The bottle was rigged for reflux and submerged in an oilbath at about 140 deg. cel. After the temp. of the liquid in the bottle reached 35 deg. everything had dissolved and it looked like plain water. Soon the whole thing began to reflux nicely. The smell reminded a bit of old wet clothes, but swim is not sure that it was the reaction that caused this.
After 2½ hour the apperance of the liquid had not changed. The erlenmeyer flask was removed from the oil bath and allowed to cool at RT. When the flask reached 70 deg, swim believed it was ok to cool it with running water. Almost immediately when the cold water touched the surface of the flask, a clear oil precipitated on top of the water. With further cooling, more appeared. Soon white flakes started to appear at the bottom. The flask was placed in the freezer for ½ an hour, till the temp. inside the liquid has droppet to 5 deg. cel. At this point the flask was white with something that did not resemble PPA nor KOCN
. The product was allowed to dry somewhat, but swim did not have enough time to let it dry completely, so he estimated there where 18 grammes(according to the original patent)(86,6 mmol). It should be noticed here that swim probably SHOULD have compensated for the missing CH2 group in the PPA to eph with 6% wt, but he did not bother as the last reaction uses only hydrochloric acid.
The wet carbamyl was put into 275 mL of water in a 500 mL FB flask and dissolved only lightly. Next 172 mL of 2M hydrochloric acid was added. No reaction could be noted. A stirr bar was put in and the whole lot was refluxed for about 2,5 hours. When the temp of the water reached about 50-60 deg celc, everything had dissolved and the liquid seemed like water again.
After 2,5 hours, swim removed the bottle and let it cool to RT. a soln of 20% Na2CO3 was added, while stirring, til no more white powder appeared. Swim was of course VERY thrilled when the white stuff precipated as an amide would not have done whis and PPA would be oily on freebase, so something had happened
. The white precipitate was gravitity filtered and some of it was dried. Swim does not have an exact yeild, but will post it later, when the whole mass has dried. It sure did look like ALOT
Test of the compound:
Chemichal:
With marquis no reaction was noted
Bioassay
:
Swim suspected that the compound would bee 8/5 times stronger than the cis/trans-4-mar, because it should be pure trans, so the doses where scaled down by this. 10 mg was placed in a test tube and smoked. Swim's pink lungs could not hold down the harsh smoke, so swim only got a light head buzz. Swims fellow chemist smoked the full 10 mg's and got really nice effects. Next 20 mg of the freebase was ingested. Within ½ a hour, swim got all warm and fuzzy in the stomach, and one hour after the ingestion swim could no longer doubt that the synth had been a 110% success. Communication was extremely easy and the mood was generally like pure euphria. Even after ingesting 25 beers, swim was really clear headed(this stuff kills any drunken state far more that meth). It also had a quite MDMA like quality to it, but it was not forced upon as with MDMA. One could rather focus on another being and get the emphatogenic effects, while "the crowd" was not loved in the same quite stupifying manner as MDMA.
The effects was strong for 6 hours and the faded. As swim was to attend a great huge concert the day afte, no sleep could be had, but the day after a funny thing was noticed: no hangover from the beers and NO seretonin/dopamine depletion like feel was notet. In fact swim could hardly tell that he had been out partying all night...
Conclusion:
This is THE most beutifull synth ever. The reactants are rather non toxic and swim really loves to use water as a solvent. The product seems really pure and the effects are way better than that of meth and MDMA. All in all: swim has found a new favorite stim
Regards
Bandil
