Author Topic: Chlorine instead of Br in Ketamine and PPA Synths  (Read 2086 times)

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wolff_kishner

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Chlorine instead of Br in Ketamine and PPA Synths
« on: July 23, 2004, 01:35:00 PM »
Is chlorine an acceptable substitute for bromine in the following syntheses?

1. Bromination of o-chlorophenyl cyclopentyl ketone (Ketamine synthesis)

2. alpha bromination of propiophenone (PPA synthesis from propiophenone)

The nature of the reactions seems to indicate that any halogen will do. Am I wrong? Is bromine specifically required?

starlight

  • Guest
I would imagine
« Reply #1 on: July 23, 2004, 03:36:00 PM »
That if you made alpha-chloro propiophenone you would get close to no yield when trying to substitute the halogen with ammonia.

Organikum

  • Guest
It might work using a pressure bomb, though.
« Reply #2 on: July 23, 2004, 09:04:00 PM »
It might work using a pressure bomb, though.